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Posted by / 09-Apr-2017 21:30

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Policosanol, as reviewed in this monograph, is a mixture of high molecular weight, primary aliphatic alcohols (waxy substances), of which octacosanol (1-octacosanol) is the main component (approximately 60%). For information regarding the octacosanol component, refer to the Octacosanol monograph. Policosanol is isolated from sugar cane wax or beeswax, but these sources may have different proportions of policosanol components. Validation of a gas chromatographic method for determining fatty alcohols that compose policosanol in five-milligram film-coated tablets . Octacosanol and related substances also are found in wheat germ oil, vegetable oils, alfalfa, and animal products. A more recent study found that policosanol in combination with tomato extract, grape procyanidins, and Oenothera biennis oil marketed as Cholactiv , given for 6 weeks, reduced LDL and total cholesterol levels. Reductions in C-reactive protein, malondialdehyde, and superoxide dismutase levels also occurred but were not statistically significant. Trials published in 2006 in the United States, Germany, Netherlands, Canada, and South Africa found no effect on blood lipid profiles at dosages of 10 to 80 mg daily over 4 to 12 weeks. Additionally, no synergy with atorvastatin was demonstrated in one of these trials. Octacosanol ingestion and its effects on metabolic responses to submaximal cycle ergometry, reaction time and chest and grip strength .

In hepatoma cells and mouse liver, policosanol promoted the phosphorylation of adenosine monophosphate kinase, the principle enzyme for catalyzing the phosphorylation of HMG Co A reductase, thereby reducing its activity.

Reports to determine constituents in policosanol from raw materials have been published.

Eight aliphatic fatty alcohols in 1 study were 1-tetracosanol, 1-hexacosanol, 1-heptacosanol, 1-octacosanol, 1-nonacosanol, 1-triacontanol, 1-dotriacontanol, and 1-tetratriacontanol, Cholesterol reduction Policosanol's impact on cholesterol is mediated through a reduction in the synthesis and degradation of the rate-limiting step of cholesterol biosynthesis, the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG Co A) reductase. Validation and interlaboratory study of a new GC analytical method for the determination of policosanol in raw material [in Spanish] .

The European Union's trade commissioner said on Thursday she hopes an EU mission to Washington will ease a transatlantic trade dispute but the bloc is preparing a list of U. imports to hit if the United States imposes tariffs on EU cars. The family, which fled violence in Honduras, slept on a hard floor in a holding cell without mattresses, she said, their clothes still wet from crossing the Rio Grande. Senate Democrats on Wednesday lashed out at Republican President Donald Trump's tax overhaul of December 2017, warning that it contains "gigantic loopholes" that could encourage companies to move plants and jobs abroad.

The White House struggled on Wednesday to contain a political outcry and confusion over U. President Donald Trump's summit with Russian President Vladimir Putin, denying Trump ever meant to say that Moscow was no longer targeting the United States. CAUGHT ON CAMERA: Police say a bicyclist who weaved past the gates blocking access to a bridge over a river in eastern Wisconsin escaped serious injury after falling into the gap that was created when the bridge started to rise.

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